Scientific Opinions For Sale

One of the greatest problems in medicine today is that academic medicine has been sold to the highest bidder. Under the guise of ‘Evidence Based Medicine’ the public has been sold fraudulent goods, and the result is that people suffer from unnecessary but lucrative procedures and take unnecessary but lucrative medications. Let me explain. Much of the data we use in medicine comes from epidemiology studies – where one thing is associated with another. It is easy to prove association, but much harder to prove that one thing causes the other, which is what we want to know.

It is very dangerous to accept data from epidemiologic studies because there are too many confounding factors. That is how we wound up with millions of women prescribed hormone replacement therapy (HRT), which turned out to be giving them cancer. In the late 1990s, there was a very strong association between women taking HRT and reduction of heart disease – about a 50% reduction. Based on this flimsy evidence, millions of women were prescribed the drug. It turns out, that when the trials were finally completed a decade or so later, that HRT did NOT reduce heart disease at all. Instead, women who took HRT were also healthier in many other ways – and these confounding factors accounted for the apparent heart disease risk reduction.

It further turns out that HRT was giving women breast cancer. When prescribing of HRT increased through the 1980s and 1990s, breast cancer also increased. But tellingly, when HRT decreased around year 2000, breast cancer also decreased by 6.7%. Almost nothing in medicine causes this type of sustained decrease in cancer, and the implication is that HRT caused cancer in millions of women. The worst part is that it was the DOCTORS that caused all these cancers, by widely prescribing a lucrative medication based only on flimsy evidence and lots of encouragement by drug companies. The problem is not the drug company, which will always do whatever it can do push its drugs. The companies duty is to make money for shareholders, not to safeguard the public. The problem is that the doctors and the universities have financial conflicts of interest by taking millions of $$$ from these companies. The duty of doctors and universities is to guard the public health and to scientific truth – which is much harder when all your funding comes from companies that have vested interests in proving benefits. Doctors and universities, and everybody else in the world knows that you don’t bite the hand that feeds you.

The New York Times reported on the recent CABANA trial of catheter ablation for atrial fibrillation. Once again, a highly invasive but lucrative procedure became widespread based on no evidence at all. But wide promotion by device companies led many doctors to inflict this on unknowing but trusting patients. How are we to protect against this? This is where evidence based medicine is supposed to shine, but demanding randomized trials to prove that certain procedures/ drugs either work or don’t. Great, right? Well, not so much. The problem is when all of these trials are paid for by industry, then the evidence is severely biased. If the evidence base is biased, then evidence based medicine is completely worthless. It’s one thing to say that Harvard researcher prove that XYZ drug cures cancer. We might believe this. But, it’s another thing to say that XYZ drug maker proves that their drug cures cancer. In this case, almost none of us believe it. The solution, if you are XYZ drug maker? Simple. Pay Harvard researchers millions of $$$ to do a study, but bias it so severely that it is a virtual certainty that XYZ drug looks like it works. Then claim that it was the Harvard researcher who proved XYZ drug cures cancer.

It’s a win-win-win situation. XYZ drug maker is happy to have ‘evidence’ that ‘proves’ their drug works. Harvard is happy with all the $$$. Researcher is happy with all the $$$ and the prestige of ‘proving’ the drug works. It actually matters almost not at all if the drug actually works or not. It’s fantastically easy to design a trial and rig the results as we’ll soon see. The only loser? Public health – it spends money on useless or dangerous medications and people die. No biggie for the universities and doctors lining their pockets.

The New York Times recently published an article describing how the NIH, the top American government health research agency pulled the plug on a $100 million trial. This study was supposed to answer the question of whether moderate alcohol intake is beneficial for health. It’s a great question, because much epidemiological data supports this hypothesis, but this data  can only be considered hypothesis generating and not definitive. So the NIH decided to do a randomized trial on this to settle the question. But, the researchers from Harvard got all the money from alcohol companies. Five large beer companies, like Carlsberg agreed to foot most of the bill for the trial.

This is crazy, and obviously puts researchers in conflict, because if they are funded by beer companies, then they will be much, much more likely to find results favourable to them. Consider the case in sugar sweetened beverages. When reviewing all the trials that linked sugar sweetened beverages (SSB) to obesity, researchers found 60 published articles. 

26 of the articles found there was no association, and 34 found a positive association – ie. that sugar was linked to obesity. Pretty close, right? If you didn’t know about conflicts of interest, then you would think that it’s equivocal whether sugar causes obesity or not. What if we were to show which papers were funded by the sugar industry?

This is what you find. 25 of the 26 (96.2%) papers showing that sugar is NOT linked to obesity were funded by the sugar industry! When you look at the papers that suggested sugar WAS linked to obesity, only 1 of the 34 (2.9%) was funded by the sugar industry. The ‘scientific’ result was based almost entirely on who pays the researchers. University professors and doctors have sold their scientific opinions and integrity to the highest bidder. For example, researchers at the University of Toronto, like Dr. John Sievenpiper are regularly trotted out in the national media saying that sugar is practically a health food. It turns out that his group receives millions of $$$ to have this opinion. It sure sounds a lot better to say that ‘Doctors at the University of Toronto say sugar not linked to obesity’ that ‘Sugar company research shows that sugar not linked to obesity’.

The same goes for medications. Dr. Aseem Malhotra, a UK cardiologist made headlines writing a paper describing one of the most insidious problems in modern medicine – too much prescription medicine, driven mainly by biased research. Statin medications are one of the most lucrative drug classes of the last 20 years. But almost all trials of these medications have been funded extensively by the companies themselves. Problem? It’s an open secret that doctors and universities are paid millions of $$$ to perform these trials, which then show that statins are the best thing since sliced bread.

Where there any non-drug-company funded trials on statins? Sure. The ALLHAT study, enrolling more than 10,000 patients showed that taking pravastatin did NOT reduce heart disease. Interestingly, this study is all but forgotten in all the drug company driven advertising to doctors about how statins are so amazingly good for health that they should be practically considered vitamin S. Virtually all drug funded studies show statins save lives. The only major non-drug funded study shows it makes little or no difference in primary prevention.

These financial conflicts of interest are not merely academic musings. People die. Take the opioid crisis for example. Drug companies paid lots of money to doctors to prescribe opioids. People got addicted, and many died. CNN showed that a group of doctors who received over $10,000 from the opioid company prescribed $1.2 million worth of drugs, compared to doctors who received less than $20 from drug companies prescribed only $34,000.

The solution is really very simply. Eliminate all financial conflicts of interest in research. That is, if a researcher works for Harvard then it is paid by Harvard, not by the drug company. If Harvard researchers want to publish a study, then it should be funded by Harvard, not some drug company that pays millions of $$$ to get a great result. If you work for a university, you should not be allowed to receive any money from anybody else. These rules are in place for almost every other profession. But for research and medicine, taking money from the highest bidder is not only allowed, it is standard operating procedure.

There will be those who argue that there will be no money for research. I say, so what? That supposes that biased research is better than none at all. That is rather like arguing that a corrupt policeman is better than none at all. I would rather have no research than biased ones.

PS. I’ll be on vacation so there will be no blog post next week for the July 1, Canada Day and July 4 holidays. Happy holidays everybody.

2018-06-20T09:48:00+00:007 Comments

About the Author:

Dr. Fung is a Toronto based kidney specialist, having graduated from the University of Toronto and finishing his medical specialty at the University of California, Los Angeles in 2001. He is the author of the bestsellers ‘The Obesity Code’ and ‘The Complete Guide to Fasting’. He has pioneered the use of therapeutic fasting for weight loss and type 2 diabetes reversal in his IDM clinic.

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Miguel Magalhaes
Miguel Magalhaes

The relationship between “good results” and “sponsorship” is too an association and not a causation. It is my belief that (nowadays) there are no big bad corrupt pharma people and doctors. What lands up happening is that the industry hires a lot of very clever people whose job is to calculate the probability of success of a given trial, and only once that probability is high will the industry engage. We can’t expect, in a capitalist world, to have the industry harm itself. The big question is 1) where are the clinical trials sponsored by public money? 2) when was… Read more »

Sten Bjorsell
Sten Bjorsell

Wow, what a devastating blow to the drug lords in their leather smelling ivory towers, if it just could reach far enough here on the. Will email a link to my doctor that I see nowadays every three years for new driving licence, as most of us over 70 are too sick to drive these days. The real problem above originates from a campaign by industry to make research more industry focussed. Sounds right that it is better to focus on on real industry problems where research could make good differences quickly than estimating the atom radius for elements that… Read more »

olle holmqvist
olle holmqvist

Association as you call it, more informatively co-variation, classic – storks and births
is what philosophers call – a necessary but not sufficient condition. It is a one-edged sword.
When absent, then there is no cause>effect relation. When present, there may still be a cause-effect situation, not excluded, but not yet proven. It suggests a possibility, to be tested by other means.

Don t let go with the bathwater…

Cathy Williams

This information was excellent and very useful to the reader!! I have two titanium valves; my mitral and my aortic valves. My cardiologist just took me off my statin drugs. He is checking me in two months. Great Doctor 👨‍⚕️

Philip McClarty
Philip McClarty

Dr. Fung,

Excellent article, with one exception…

“These rules are in place for almost every other profession”

I would argue that most professions are actually worse than ours in this regard, at least in the US, and this is a pretty outlandish statement to further reduce confidence in medical community, the majority of whom really do care about people beyond money.


I am very pleased to see that the comments are starting to show some clear thinking about the specific attacks on the medical profession ethics in research….as opposed to the repetitive “demogoguing” of Dr Fung. I suppose he knows that it is red meat for the faithful….but in substantial ways fighting the last war. Yes, there are problems and potential problems. Mr (?Dr) Mclarty …is right. The sleaziest of professions…….lawyers…have absolutely none of these rules . In fact, referral fees, kickbacks, and all sorts of normal suspect financial dealings are encouraged. I, of course, enthusiastically endorse Universal Law Care.


Fat chance of anything changing, Dr. Fung.

I like you, but we aren’t going to change a damn thing. Medicine, and all major industries in America, are corrupted top to bottom by big money.